PAPPA2 and hypertensive disorder: Specifically, the m6A reader IGF2BP3 increases the stability of circRNA PAPPA2 as a result of its interaction with m6A. IGF2BP3 and circRNA PAPPA2 levels are decreased in preeclamptic placentas compared with normal placental tissue, further impairing trophoblast cell invasion and leading to abnormal uterine spiral artery remodelling, which is a key pathogenic determinant of hypertension in pregnancy [87].