Another study on endometrial cancer also confirmed that m6A methylation levels were reduced in endometrial cancer cells and that m6A mRNA methylation could regulate the ERK/NF-κB/AKT signalling pathway through the PAPPA/IGFBP4 axis to induce proliferation and tumour formation in endometrial cancer cells [128]. This evidence concerns the gene IGFBP4 and endometrial cancer.