PADI2 and endometrial cancer: In addition, it has been reported that IGF2BP1 is involved in the guanylation of arginine in endometrial cancer, and the PADI2/MEK1/ERK signalling pathway-mediated dysregulation of IGF2BP1 leads to the upregulation of SOX2 expression, resulting in the malignancy of endometrial cancer cells [129].