BACH2 and atrial fibrillation: Among the three target mRNAs of GAS6-AS1 in our ceRNA network, BACH2 has higher inference scores for AF and Stroke, at the same time, Bach2 has been suggested as an influential immune-regulating transcription factor in T helper 2 (Th2), Follicular T helper (Tfh), regulatory T cell (Treg), B cells and plays a key role in Th2 immune response previously [47].