GLIS2 and psoriasis: Targeting by GLI1 and GLI2 was also increased in melanoma confirming their association to drug resistance in melanoma cell lines [63] and was associated with promoter hypomethylation of MIR6893. According to TargetScan [10], MIR6893 regulates two related TFs, Glis Family Zinc Finger 1 and 2 (GLIS1 and GLIS2), and both have been reported to be involved in psoriasis [64], an inflammatory skin condition, which may indicate that they play a similar role in melanoma.