The area postrema, a circumventricular organ located in the dorsal medulla of the brain which densely expresses GLP-1 receptors, may have a role mediating the effects of GLP-1 RAs [39]; preclinical models of hypertension support an antihypertensive effect of GLP-1 RAs by activating these neurons and suppressing sympathetic nerve activity [40]. This evidence concerns the gene GLP1R and Hypertension.