JAK3 and Autoimmunity: Additionally, PRKDC encodes DNA-dependent protein kinase catalytic subunit (DNA-PKcs), which is crucial for DNA double-strand break repair and V(D)J recombination [52]. Missense mutation of PRKDC results in deficient DNA-PKcs, which is associated with the inflammatory disease with organ-specific autoimmunity [53], as well as the loss of mature T and B cells and jak3 in T and putative Natural Killer cells [54].