He et al. have revealed that oridonin is a covalent inhibitor of NLRP3 inflammasome, exerts preventive or therapeutic effects on mouse models of peritonitis, gouty arthritis, and type 2 diabetes by inhibiting the activation of NLRP3 inflammasome, thus further effectively inhibiting NLRP3-related diseases [18]. This evidence concerns the gene NLRP3 and type 2 diabetes mellitus.