CD274 and colorectal carcinoma: In the current study, we found that the prevalence of aberrant PD-L1 genetic alteration was lower in CRC (10.2%) comparing to that in cHL, but much higher than 0.7% amplification rate (843 cases in 118,187 tumor samples from commercial database) reported in a recent study, which includes more than 100 types of solid tumor [38].