The CRRS prognostic model for calculating HCC risk score was as follows: risk score = (0.1065 * FLVCR1) + (0.3748 * CENPE) + (− 0.0082 * LCAT) + (− 0.0019 * CYP2C9) + (0.0019 * NQO1). The gene discussed is CENPE; the disease is hepatocellular carcinoma.