We hypothesized that venous congestion rather than pulmonary hypertension would be more strongly associated with prognosis.<h4>Methods and results</h4>895 patients with chronic heart failure (CHF) (median (25th and 75th centile) age 75 (67-81) years, 69% men, LVEF 44 (34-55)% and NT-proBNP 1133 (423-2465) pg/ml) were enrolled. This evidence concerns the gene NPPB and pulmonary hypertension.