To investigate the potential of ATPase-competent cBAF complexes as host-directed therapeutic targets for coronavirus disease 2019, we next evaluated the effect of two analogous orally bioavailable small-molecule inhibitors of SMARCA2/4 ATPase activity, Comp12 and Comp14, on SARS-CoV-2 infection55 (Fig. 4a). Here, SMARCA2 is linked to COVID-19.