Interestingly, no TRP53 pathway alterations were detected in any of the sgTfap4/Eμ-MYC/Cas9 lymphomas tested by Western blotting for the levels of TRP53 and p19/ARF proteins (high levels of these proteins are an indicator for mutations in the Trp53 gene and/or TRP53 pathway defects) (Fig. 2A, B) [28]. Here, CDKN2A is linked to lymphoma.