To better understand how TFAP4 deletion contributes to c-MYC-driven lymphoma development, a pre-leukaemic analysis was performed whereby recipient mice transplanted with either sgTfap4 or sgControl transduced Eμ-MYC/Cas9 HSPCs were harvested 3 weeks post-transplantation, a time point early during lymphomagenesis when their B lymphoid cells are not yet fully transformed. Here, TFAP4 is linked to lymphoma.