Several AMPs (e.g., polymyxin, vancomycin, and daptomycin) have already been approved for human use, and other natural and synthetically designed AMPs are in various stages of clinical development.102,103 The production of new synthetic antimicrobials through chemical and structural modification of natural products, as well as the biomanufacturing of natural antimicrobials, is an area of high significance that may play a major role in resolving orthopedic PJIs and other biotic and abiotic infections. This evidence concerns the gene ADSL and infection.