Actually, main members enrolled in HR repair pathways, such as p-ATM and p-P95/NBS1 could be remarkably induced by CPT in the BR MM cell compared with in WT MM cells (Supplementary Fig. 4c), which phenotype was similar with overexpressing of HP1γ in MM cells (Supplementary Fig. 4d). The gene discussed is ATM; the disease is Miyoshi myopathy.