Literature search found that Aldh7a1 and Aldh3b1 are the members of Aldh, and Aldh7a1 has been linked to pyridoxine-dependent epilepsy.46 To explore the possible relationship between Aldh3b1 and tutin, the effects of pyridoxine were tested on tutin-treated mice. Here, LDHA is linked to pyridoxine-dependent epilepsy.