Increased NLRP3 as well as apoptosis-associated speck-like protein (ASC) expression and Casp1 activity were linked with heightened expression levels of mature IL-1β and IL-18 in COVID-19 samples.4–6 Although prior analyses were unadjusted, the magnitude of the inflammasome activation along with IL-1β and IL-18 levels were also proposed to correlate with disease severity and clinical outcomes in patients with COVID-19.4,7. Here, IL1B is linked to COVID-19.