Moreover, PSPC1, as a substrate of nuclear PTK6, is the contextual determinant of PTK6 nucleocytoplasmic shuttling and modulates the switch of tumor-suppressive PTK6 in the nucleus of normal [38].Through a series of rescue experiments, it was confirmed that as a novel lncRNA, LOC105369504 exerted tumor suppressive activity to inhibit cell proliferation and metastasis in CRC by regulating PSPC1. This evidence concerns the gene PTK6 and colorectal carcinoma.