(Patho)physiological conditions such as hypoxia (Kikuchi et al, 2009; Chun et al, 2010) (mimicked by dimethyloxalylglycine, DMOG [Zhang et al, 2016]), EGF, and PGE2 also play a role in CRC and KRAS TME (Smakman et al, 2005; Greenhough et al, 2009; Hsu et al, 2017) and were selected as growth conditions here. Here, KRAS is linked to colorectal carcinoma.