KRAS and colorectal carcinoma: To probe different “genetic contexts,” we exogenously expressed KRAS WT and three oncogenic mutations frequently found in CRC (G12V, G12D, and G12C) to probe different “genetic contexts.” To probe different “culture contexts,” we grew Caco-2 cells in various growth media mimicking tumor microenvironments (TME) that are known to impact CRC maintenance, progression, and metastasis, which have been described earlier in connection with oncogenic KRAS.