CD8A and neoplasm: The molecular mechanism believed to contribute to the most significant abscopal effects is neoantigen expression.35 Death of an irradiated tumor releases substantial necrotic tissue and particles that are collected by antigen-presenting cells and thus presented to the CD8+ T cells.36 Furthermore, irradiated tissue is believed to release of damage-associated molecular patterns, which further enhance the immune response.37 Work on how to combine agents that stimulate or increase the activation of antigen-presenting cells after delivery of radiation is continuing.38,39