These compounds either by employing cereblon (CRBN)- (ARV-110, TD-802, ARD-2128) or von Hippel-Lindau (VHL)- (ARCC4, ARD-266, ARD-69, ARD-61) mediated degradation, effectively inhibit tumor proliferation in both androgen-dependent as well as CRPC models. This evidence concerns the gene ADI1 and neoplasm.