CREBBP and diffuse large B-cell lymphoma: In line with this conclusion, KMT2D acetylation was completely abolished when cells were cotransfected with vectors expressing two DLBCL-associated, enzymatically inactive CREBBP proteins, including a C-terminal truncation mutant lacking the HAT domain and a HAT missense mutant (R1446L) we previously demonstrated to be catalytically inactive (6) (Fig. 5E).