The EBL (< 250 g, 687.6 cc vs 250–500 g, 785.7 cc vs ≥ 500 g 1062.5 cc, p = 0.01), differences of Hb (< 250 g, 1.8 mg/dL vs 250–500 g, 2.3 mg/dL vs ≥ 500 g 3.5 mg/dL, p = 0.02), postoperative transfusion rate (< 250 g, 35.1% vs 250–500 g, 85.7% vs ≥ 500 g 87.5%, p <0.001) were significantly associated with the increase of myoma weight. This evidence concerns the gene GSTM1 and benign muscle neoplasm.