PPARG and pulmonary arterial hypertension: Additionally, bosentan competitively bound to ET-1 receptors and inhibited the miR-27a/PPARγ/ET-1 signalling pathway, thereby delaying PASMC proliferation and affecting PAH development [41].Our study also suggested that the PPAR signalling pathway was related to PAH regulation and the enrichment of upregulated mRNAs in this pathway was relatively high.