We then performed ROC analysis of all follow‐up times, excluding participants in cohort A who met the heart failure rule‐in criteria for NT‐proBNP levels or reported any heart disease risk factors and compared them with participants who reported at least 1, 2, or 3 study‐designated heart disease risk factors in cohort B (Table 2; Figure 2, bottom). This evidence concerns the gene NPPB and heart failure.