CXCL8 and Stroke: Neutrophils are attracted to the ischemic tissue after stroke and activated by tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-8 (IL-8) secreted by microglia or astrocytes, followed by the release of NETs, which may inversely activate glial cells and lead to neuronal damage [11].