Currently, there are around 20 known human amyloiddiseases.5 Deposition of protein aggregatesassociated withthese diseases can occur at localized tissues (e.g., localized insulin-derivedamyloidosis or medullary thyroid carcinoma), associated with the centralnervous system (e.g., Alzheimer’s and Parkinson’s diseases),or systemic (e.g., apolipoprotein amyloidosis or hereditary non-neuropathicsystemic amyloidosis) with a spontaneous or hereditary nature. This evidence concerns the gene INS and amyloidosis.