In contrast, a previous study revealed that mRNA expression levels of several m6A modulators were decreased in the whole islets of T2DM patients compared to controls, including YTHDF1, YTHDF3, METTL14, FTO, pancreatic and duodenal homeobox 1 (PDX1), and ALKBH5. This evidence concerns the gene YTHDF1 and type 2 diabetes mellitus.