Mutations in the human gene for Prx (PRX, MIM no. 605725) on chromosome 19q13.2 have been associated with autosomal recessive Charcot Marie Tooth disease type 4F (CMT4F, MIM no. 614895) and both autosomal dominant and recessive sub-forms of Dejerine-Sottas syndrome/neuropathy (DSS/DSN, MIM no. 145900). Here, PRX is linked to Charcot-Marie-Tooth disease type 4F.