ADAMTS10 and Microspherophakia: Mutations in ADAMTS10 (MIM no. 608990) on human chromosome 19p13.2 have been associated with Weill-Marchesani syndrome 1 (WMS1, MIM no. 277600)—a rare autosomal recessive connective tissue disorder characterized by short stature, brachydactyly, joint stiffness, occasional heart defects, and eye anomalies, including severe myopia (94%), microspherophakia (small, spherical lens, 84%), glaucoma (80%), ectopia lentis (lens displacement, 73%), and cataract (23%) (Faivre et al. 2003; Dagoneau et al. 2004).