Using whole-exome sequencing and variant analysis of Em/J and CFW mice, we excluded over 450 known genes for inherited and age-related forms of cataracts—with or without other ocular and/or systemic abnormalities—including those for lens crystallins, membrane and cytoskeletal proteins, DNA or RNA-binding proteins, along with many genes for syndromic/systemic forms of cataract (https://cat-map.wustl.edu). This evidence concerns the gene DNM2 and cataract.