In the wounds of individuals with hyperglycemia, protein kinase B (AKT) phosphorylation can directly phosphorylate eNOS and induce NO production after activation of the PI3K/AKT‐eNOS pathway, serving as a key regulator of vascular protection, maintaining endothelial cell function, and promoting angiogenesis, thus indicating its role in diabetic wound healing.78 The gene discussed is AKT1; the disease is Hyperglycemia.