Luo et al. reported that there is a certain correlation between the CDKN2A expression as well as immune invasion and the risk of HCC occurrence and that the high expression of CDKN2A is negatively correlated with the overall survival rate and prognosis of patients [55], which may be related to the participation of CDKN2A in the MAPK signaling pathway and the diversity of liver cancer [56]. This evidence concerns the gene CDKN2A and liver cancer.