TP53 and hepatocellular carcinoma: Among them, the genes such as TP53 (cellular tumor antigen p53), CTNNB1 (catenin beta-1), TTN (titin), and MUC16 (mucin-16) had a very high mutation rate in HCC, with their mutation methods all mainly missense mutation, and some genes were also mutated by such methods as frame shift mutation and nonsense mutation.