APOE and Mental deterioration: When significant variables from baseline were entered into a multinomial logistic regression model, significant risk factors of cognitive decline were higher age (OR = 1.05, 95% CI: 1.00–1.11), low education (≤ high school; OR = 1.46, 95% CI: 1.07–1.98), poor self-rated health (OR = 1.78, 95% CI: 1.16–2.71) and APOE-ε4 (OR = 1.44, 95% CI: 1.06–1.95).