CDKN1B and viral infectious disease: Moreover, the expression of p27 was altered due to certain bacterial and viral infections; in vitro and in vivo studies have highlighted the resistance of Helicobacter pylori-infected gastric cancer cells to apoptosis which was associated with low expression levels of p27 [29],[30], while murine herpesvirus 68 (MHV 68) infections might alter the fate of p27 [31].