OXTR and injury: Oxt has anti-injurious and antinociceptive hormonal effects on neuropathic pain (Xin et al., 2017) induced by nerve injury, which is mediated by its receptor (OTR) and likely occurs due to co-localization of these neurons within OTR-binding sites, such as the spinal dorsal horn (Veronneau-Longueville et al., 1999; Wrobel et al., 2011).