The past and current literature have indicated that neurotransmitters and neuromodulators systems such as norepinephrine (Joshi and Chandler, 2020), dopamine (Hasbi et al., 2020), serotonin (Zhang et al., 2017), GABA (Cerne et al., 2022), and oxytocin (Tamborski et al., 2016; Aulino and Caldwell, 2020) seemed to be strongly involved in pain-related sexually dimorphic mental disorders (Dazzi and Scicchitano, 2014). The gene discussed is OXT; the disease is mental disorder.