PRKN gene (PARK2) mutation was initially reported in a sample of Japanese families with juvenile parkinsonism and was the most common cause of autosomal recessive PD, which was located on Chromosome 6 and was particularly prevalent in women with Young-Onset PD (YOPD), with the onset of PD before the age of 30 years (7, 8, 10). This evidence concerns the gene PRKN and Parkinson disease.