Other anti-PD medications, including anticholinergics, catechol-O-methyltransferase (COMT) inhibitors, and monoamine oxidase-B (MAO-B) inhibitors, are rarely used as monotherapy or alone with levodopa or combined with dopamine decarboxylase inhibitors during pregnancy, and adverse effects on fetal development have been reported. This evidence concerns the gene COMT and Parkinson disease.