EFEMP1 and open-angle glaucoma: Previous studies have found that altered EFEMP1 expression is closely associated with many ocular diseases (Springelkamp et al., 2015), mutations in EFEMP1 expression (R345 W) may lead to Malattia Leventinese (Tsai et al., 2021), and the expression of EFEMP1 is abnormally high in the ciliary body of patients with open-angle glaucoma (Collantes et al., 2022).