Although several studies have demonstrated that GPR43 activation improves hyperglycemia and IR in T2D mice (Huang et al., 2020; Li Y. J. et al., 2020), there was also evidence that GPR43-deficient mice fed a high-fat diet (HFD) improved glucose tolerance and impaired insulin signaling (Lu et al., 2021). Here, INS is linked to type 2 diabetes mellitus.