Currently, the main methods used to combat glucose toxicity are to reduce blood glucose sources, increase insulin sensitivity, stimulate insulin secretion, and reduce kidney reabsorption of glucose (Palanisamy et al., 2018; Foretz et al., 2019; Gilbert and Pratley, 2020), which are not effective in protecting β cells or reversing diabetes status in patients diagnosed with diabetes (Aroda et al., 2017). This evidence concerns the gene INS and diabetes mellitus.