The development of the CD103+DC subgroup is regulated by the transcription factor IRF8 and cytokine FMS‐like tyrosine kinase 3 ligand (Flt3L), which promote the secretion of chemokines C‐X‐C motif chemokine ligand 9 (CXCL9) and CXCL10,8 recruit and induce cross‐priming of anti‐tumor CD8+ T cells and play a unique role in promoting anti‐tumor immunity.9, 10, 11, 12, 13. The gene discussed is IRF8; the disease is neoplasm.