At the same time, in our previous studies, we also found that blocking SIGIRR could eliminate the inhibition of cytotoxic T‐cell effectors, and the formation of the IL‐37–SIGIRR–IL‐18Rα ternary complex was very important for the anti‐tumor immunosuppressive properties of IL‐37.21, 47. This evidence concerns the gene IL18R1 and neoplasm.