However, an in vitro study demonstrated that overexpression of miR-182 in Jurkat T cells, a CD4+ cell line derived from human acute T cell leukemia, downregulated Foxo1 expression and promoted the polarization of the transduced T cells to Foxp3+ T cells, of which some were Foxp3+IL-17+ cells (56). Here, FOXP3 is linked to T-cell acute lymphoblastic leukemia.