CXCR2 and Sepsis: In addition, administration of the glycolytic inhibitor 2-deoxyglucose (2-DG) restored the ability of neutrophils to cluster to infected abdominal lesions in sepsis mice, partially reversed glycolytic-induced neutrophils migration dysfunction and down-regulated CXCR2 expression, suggesting that 2-DG may be a potential therapeutic strategy (329).