TNF and neoplasm: Strikingly, for cDC2s stimulated with R848, the initial abrogation of their cytokine production (IL-12p40/p70 and TNFα) by tumor cells was abolished upon pre-treatment with soluble WGA (blocking GlcNAc residues) (Figures 6A–B, S12A), suggesting that GlcNAc is a potential deleterious glycan responsible for the negative impact of tumor cells on cDC2s upon TLR triggering.