In opposition, pre-treating tumor cells with soluble UEA-I, RPL-αMan or RPL-Gal2 (blocking Fuc, Fuc/Man or Gal residues respectively) increased the positive impact on cDC1s and pDCs, boosting the production of IFNλ1 by cDC1s and/or IFNα by pDCs (tumor cells #1, #2 and #4 for UEA-I, tumor cells #2 and #4 for RPL- αMan and all tumor cells for RPL-Gal2) when compared to co-culture with untreated tumor cells (Figure 5B). Here, LGALS2 is linked to neoplasm.