CCL5 and Pruritus: Decreasing serum IgE, epidermal inflammatory cytokines, such as IL-4, IL-13, IL-31, RANTES, and TARC. Repairing skin barrier by restoring transepidermal water loss, enhancing stratum corneum hydration, and upregulating the expression levels of epidermal differentiation proteins. Reducing IL-31/TRPA1-mediated pruritus and activation of JAK/STAT signaling pathway