TLR4 and diffuse large B-cell lymphoma: Recently, it was reported that Enterococcus faecalis translocated endotoxin to the liver and increased the expression of liver proliferation genes, which are dependent on TLR4-MYD88 signaling, promoting hepato-carcinogenesis (53)The MYD88 activates NF-κB signaling in response to TLR stimulation and also IL-1 and IL-18 receptors and MYD88 mutations are believed to be closely associated with non-GCB type DLBCL development (54).