This abundance is often related to lower absolute counts of total lymphocytes, CD3+T lymphocytes, and CD4+T cells, so it was hypothesized that g_Prevotella_2 and s_un_g_Prevotella_2 may contribute to lymphoma development by reducing CD4+ Th cell and lymphocyte numbers, weakening the host’s anti-lymphoma immunity. The gene discussed is CD4; the disease is lymphoma.