IL6 and neoplasm: Critically, the IL-6 signaling pathway is a negative predictor in aggressive DLBCL (45), so it is hypothesized that g_Akkermansia may increase IL-6 levels and predict a greater tumor load in DLBCL patients, and in this study, the bacterium was elevated in DLBCL patients, especially in those with advanced DLBCL, however it is not possible to infer a causal relationship between the two.