CEACAM1 and breast neoplasm: While many studies reported that the binding of SHP-1/2 to the tyrosine-phosphorylated Immunoreceptor tyrosine-based inhibitory motif (ITIM) of the CEACAM1-L variant supports the inhibitory effects of the ITIM on colon, prostate, and breast tumor cell growth (105–109), the role of ITIM and SHP-1/2 upon H. pylori infection of the gastric epithelial cells has not yet been studied intensively.