This phenomenon has been demonstrated in graft versus host disease mouse models as VISTA signaling through a VISTA-agonist-antibody has been shown to result in direct suppression of effector T cells rather than direct effects on Treg cells with concomitant reduction in IFN-γ and TNF-α levels in CD4+ and CD8+ T cells (88). This evidence concerns the gene CD8A and graft versus host disease.