It was found that among all clinical indicators, only N stage (PFS, HR=5.2, p=0.004) is still a dangerous risk factor for the survival of tumor patients, while immune indicators, such as CD4 in TLS (OS, HR=0.317, P=0.008) was independent protective factors, and its value in clinical application needs further investigation (shown in Table 3). Here, CD4 is linked to neoplasm.