MRC1 and Sepsis: Proteins in the S100 family are among the most abundant cytoplasmic proteins in myeloid-differentiated cells that are released during activation of phagocytes and known to play a significant role in the pathogenesis of sepsis (52–54), while MRC1 is a C-type lectin receptor and expression is generally considered a marker of a more M2-like or regulatory macrophage polarization (55).