SREBF2 and neoplasm: In addition, Etienne Ho Kit Mok et al. showed that SREBP2-mediated cholesterol biosynthesis is crucial for the increase of hepatic CSCs, and deletion of sterol-regulatory element binding protein 2 (SREBP2) and its chaperone SCAP conferred sensitivity to tyrosine kinase inhibitors in tumor-bearing mice (Li et al., 2022; Mok et al., 2022).