EGFR and neoplasm: Dysregulation of the Ras-Raf-Mek-ERK, PI3K-Akt-mTOR, PLC- γ 1, signal transducer and activator of transcription, and Src pathways downstream of EGFR are involved in tumor cell proliferation and apoptosis, which are tightly associated with sorafenib resistance (Swanton, 2017).