Zhang et al. found that microbial-derived staphylococcal superantigen-like protein 6 could inhibited glycolysis by blocking the activation of PI3K/Akt/HIF-1 by CD47 to enhance the sensitivity of HCC cells to sorafenib (Zhang et al., 2020) (Figure 2A). This evidence concerns the gene AKT1 and hepatocellular carcinoma.