Another experiment also confirmed that in HCC, ANXA3-mediated autophagy activation and attenuation of the PKCδ/p38-dependent apoptotic signaling pathway are involved in the development of sorafenib resistance, and HCC cells can be resensitized to sorafenib by inhibiting the expression of ANXA3 protein (Tong et al., 2018). The gene discussed is PRKCD; the disease is hepatocellular carcinoma.