Dysregulation of the Ras-Raf-Mek-ERK, PI3K-Akt-mTOR, PLC- γ 1, signal transducer and activator of transcription, and Src pathways downstream of EGFR are involved in tumor cell proliferation and apoptosis, which are tightly associated with sorafenib resistance (Swanton, 2017). This evidence concerns the gene EPHB2 and neoplasm.