In a pharmacometabolomics study (Combrink et al., 2019), time-dependent drug-induced host-metabolome variations in urinary metabolome were observed in a cohort of 23 TB patients before and after 1, 2, 4 weeks intensive phase tuberculosis therapy, including reduction in the oxidative stress levels (aconitase, formylglycine-generating enzyme, α-ketoglutarate dehydrogenase, and succinate-semialdehyde dehydrogenase), upregulated urea cycle, and altered insulin production, as well as time-dependent induction and inhibition of several enzymes in response to the drugs. Here, INS is linked to tuberculosis.