Two recent published articles have found the relative reduction of T lymphocytes within the tumor microenvironment for TSC related LAM (Guo et al., 2020) and AML (Wang et al., 2022b), suggesting adoptive transferred PMEL-specific CD8+ T cells may be effective because this cytotoxic T cells can specifically attack PMEL + tumor cells (Hanada et al., 2019; Han et al., 2020). The gene discussed is CD8A; the disease is lymphangioleiomyomatosis.