In 2001, Stone, C. H. assessed the relationship between the immunophenotypic and ultrastructural profile of renal angiomyolipoma and found that all 27 renal angiomyolipomas stained positive for HMB-45, regardless of their identification as epithelioid, spindle, or adipocytic cells, suggesting all components were coming from a common cell ancestor and providing a unitarian concept for renal angiomyolipoma (Stone et al., 2001). Here, PMEL is linked to kidney angiomyolipoma.