Only 14 patients with disseminated coccidioidomycosis (DCM) had been reported in the literature having mutations impairing immune function – 12 within the IL-12/IFN-γ and STAT3 signaling pathways (107–109) and a 5-year-old male with CTPS1 deficiency - a disorder of impaired lymphocyte proliferation (110). The gene discussed is IFNG; the disease is coccidioidomycosis.