The potential correlation of CRGs with m6A modification in HCC was evaluated, and the differential expression of 20 m6A-related genes (RBM15B, VIRMA, IGF2BP29, HNRNPA2B1, IGF2BP1, YTHDF3, IGF2BP3, HNRNPC4, RBM15, RBMX, METTL14, YTHDC2, METTL3, ZC3H13, WTAP, YTHDF1, YTHDC1, FTO, YTHDF2) were found between the C1 and C2 subgroups. The gene discussed is YTHDF2; the disease is hepatocellular carcinoma.