The results showed that these 19 CRGs were mainly involved in extracellular matrix organization, regulation of DNA metabolism, cell-matrix adhesion junction, extracellular matrix components, cell adhesion molecule binding, collagen binding and other biological functions in HCC, and they were closely related to focal adhesion, extracellular matrix-receptor interaction, HCC, cell cycle, PD-L1 expression, PD-1 checkpoint, PI3K-Akt, TGF-β, NOD-like receptor and other signaling pathways. This evidence concerns the gene PDCD1 and hepatocellular carcinoma.