CDKN2A is highly expressed in various cancer tissues such as liver cancer and kidney cancer and plays an important prognostic role in many cancers (Ai et al., 2003; Zeng et al., 2018; Christodoulou et al., 2020; Ji et al., 2020; Xande et al., 2020). The gene discussed is CDKN2A; the disease is liver cancer.