HCC patients had a lower survival rate when CDKN2A (HR = 1.75, p = 0.002), DLAT (HR = 1.7208, p = 0.0024), DLST (HR = 1.5484, p = 0.0141), GLS (HR = 1.5001, p = 0.0222) and PDHA1 (HR = 1.4981, p = 0.0226) were highly expressed. This evidence concerns the gene CDKN2A and hepatocellular carcinoma.