In addition, the clinical analysis showed that HCC tissues with prognostic CRG mutations upregulated the expression of cancer-related signaling pathways (p = 1.051 × 10−3, Figure 9F), tumor burden mutation (TMB) (p = 1.490 × 10−3, Figure 9G), MSIsensor Score (p = 1.426 × 10−3, Figure 9H), as well as hypoxia scores, including Buffa Hypoxia Score (p = 2.329 × 10−3, Figure 9I), Ragnum Hypoxia Score (p = 3.249 × 10−5, Figure 9J) and Winter Hypoxia Score (p = 9.727 × 10−4, Figure 9K). The gene discussed is CHD7; the disease is cancer.