Finally, a key mRNA-miRNA-lncRNA triple regulatory network associated with HCC prognosis was established, which included 3 mRNAs (CDKN2A, GLS, and PDHA1), 3 miRNAs (hsa-miR-125b-5p, hsa-miR-101-3p and hsa-miR-23c) and 6 lncRNAs (GSEC, PTPRG-AS1, CYTOR, DANCR, TRAF3IP2-AS1 and DLEU2). This evidence concerns the gene PDHA1 and hepatocellular carcinoma.